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Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants
(University of Missouri--Columbia, 2005)
The drug 4-nitroquinoline 1-oxide (4NQO) displays both carcinogenic and antitumor effects, a well known characteristic of many chemotherapeutic drugs. In addition 4NQO shares a similar operating mechanism with the commonly ...
Sphingolipid metabolic enzymes modulate anticancer drug resistance
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] One of the most challenging aspects of cancer therapy today is the problem of drug resistance. The aim of our research is to understand the molecular basis of anticancer drug...